Foxo Transcription Factors Blunt Cardiac Hypertrophy by Inhibiting Calcineurin Signaling
نویسندگان
چکیده
منابع مشابه
Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling.
BACKGROUND Cellular hypertrophy requires coordinated regulation of progrowth and antigrowth mechanisms. In cultured neonatal cardiomyocytes, Foxo transcription factors trigger an atrophy-related gene program that counters hypertrophic growth. However, downstream molecular events are not yet well defined. METHODS AND RESULTS Here, we report that expression of either Foxo1 or Foxo3 in cardiomyo...
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ژورنال
عنوان ژورنال: Circulation
سال: 2006
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.106.637124